Showing posts with label Obesity Research Journal. Show all posts
Showing posts with label Obesity Research Journal. Show all posts

Sunday, June 9, 2019

Diabetes open access journals- Lupine Publishers



Background: Hand-grip strength (HGS) has been shown recently to help in predicting disease outcomes and assessing health risk, particularly in cardiovascular and metabolic disease. Studies confirming its link to diabetes (T2DM) suggest there is potential for its use as simple screening tool. This study examined this possibility in a developing-world population, in a cohort of Tongan diabetics.

Methods: HGS was measured in a randomly selected cohort of patients, comprising in total 149 patients, of which 91 with and 58 without T2DM. Other measurements recorded included patient demographics, blood pressure and date of diabetes diagnosis.

Results: HGS was found to reduce significantly with age in all groups and it also related to BMI in males. Binary logistics regression models were produced using ‘HGS,’ ‘Age’ and ‘BMI’ which had a sensitivity of 82-84% (M/F) and specificity of 50-57%.

Conclusion: This study uses one of the well-known effects and complications of T2DM, affected hand grip strength of sufferers, as a parameter in a ‘tool’ to predict the presence of the disease showing very good sensitivity. Further research is needed into the more general utility of the tool, while further work may help identify among the diagnosed those who would benefit from specialist treatment.

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Monday, April 1, 2019

Journal of Diabetes and Obesity- Lupine Publishers

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Monday, March 25, 2019

Journal of Diabetes Research Impact Factor- Lupine Publishers



Background and Objective
The association between diabetes and thyroid dysfunction were studied. To estimate retrospectively the frequency of hypothyroidism in patients with type 2 diabetes (T2DM) in Saudi community-based hospital.
Design
We analyzed retrospectively 3760 participants whom are between the age 20 to 98 years. All patients were from the population of the Primary health centre at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. All data were collected on the basis of a review of electronic medical data. Patients with TSH above the normal range of TSH for our laboratory reference (4.2 MIU/L, history of hypothyroidism and taking thyroid replacement therapy were included. Patient who are pregnant were excluded.
Results
Out of the initial screening of 6023 subjects, 3760 subjects were included. There were 861 (22.9%) male and 2899 (77.1%) were female with mean age 44.9±15.8. The mean TSH value was 4.3±8.1. Among them we found 1521 (40.7%) and 1086 (28.9%) cases with T2DM and hypothyroidism respectively. Among cases of T2DM, there were 467 (30.7%) with hypothyroidism. There were 86 (18.4%) cases were male and 381 (81.6%) were female with male to female ratio of 1 to 4.4, p< 0.0001. Cases with hypothyroidism were non significantly older than cases with no hypothyroidism, 55.2±12.6 vs. 54.9±13.2 respectively, p=0.6. Cases with hypothyroidism were non significantly showed no differences in HbA1c than cases with no hypothyroidism, 7.9±2.3 vs. 8.1±2.1 respectively, p=0.2. Hypothyroidism was more prevalent in the sixth decade (32%), figure 1. Hypothyroidism was significantly more prevalent in females between the third to the seventh decades as compared to males. Male was no significantly more prevalent than females in the eighth and ninth decades.
Conclusion
We conclude that despite the limitations of this hospital-based retrospective study, hypothyroidism is highly prevalent in cohort of Saudis with T2DM. The majority of our patients with primary hypothyroidism were predominantly females. These two observations remain to be validated by population-based studies. In the absence of registry data, larger cooperative studies involving diverse population samples from multiple centers could help to provide further information on the true frequency nationally. Based on a high prevalence of hypothyroidism among Saudi T2DM patients, routine screening for hypothyroidism is highly recommended in Saudi diabetic population.


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Monday, March 18, 2019

Diabetes Open Access Journals- Lupine Publishers



From the beginning time people go for bowel outside in thefields and when he was doing bowel that time how much time he spends that place he must live in the environments of the bowel odor. And till now after many improvements of toilets we must live in odor of poop in our toilets. we use perfume detergent cake and any kind of chemicals to remove odor, but odor mixed with perfume or chemical and disturb our nose to brain and our mood become distress.


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Monday, February 25, 2019

Obesity Research Journal- Lupine Publishers



Diabetes Mellitus is a chronic disorder characterized by hyperglycemia due to insulin deficiency or insulin resistance. There is no permanent cure for Diabetes. Only way is to replace insulin producing beta-cells. Whole pancreatic transplantation and purified pancreatic islets transplantation are the answer to cure for diabetes. But scarcity of suitable donor and morbidity, high cost involved are limiting factors for pancreatic transplantation. Islet cell transplantation is less invasive procedure and safer than total pancreatic transplantation established in year 2000. Isolated islets carry less antigenic property.


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Monday, February 18, 2019

Obesity Journal- Lupine Publishers



Since 2010, the American Diabetes Association has endorsed both HbA1C (A1C) and fasting plasma glucose (FPG) to determine diabetes risk. Given the discordance between classifications based on FPG and A1C and higher A1C levels among African Americans (AAs) than whites, we sought to examine the prevalence of normoglycemia, prediabetes, and diabetes among a community sample of adult AAs (n=704) screened for enrollment in a randomized Diabetes Prevention Program (DPP). We conducted a retrospective analysis to estimate the degree of discordance between risk categories based on FPG and A1C and examine the risk factors that predicted A1C and FPG levels. To determine differential effects on risk categories defined using FPG and A1C, we examined the effects of the program on the measures at 12 weeks post-intervention among the intervention arm participants.

The tests revealed different prevalence levels at baseline: A1C, 36.2% normoglycemia, 52% prediabetes and 11.8% diabetes; FPG, 81.1%, 16.8%, and 2%, respectively. There was discordance among A1C and FPG and among the risk categories (p<0.001). Both final regression models included age and waist circumference as predictors. For FPG, additional predictors were family history of diabetes and male gender. Post intervention, only those classified in the prediabetes category defined in terms of either test demonstrated intervention effects. Screening test choice results in different sample composition; both A1C and FPG respond to intervention effects among individuals classified in the prediabetes group only. These results have implications for research and clinical practice.


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Monday, February 11, 2019

Diabetes Journals- Lupine Publishers



Low grade inflammatory condition which is predominately cytokine-mediated is observed to be closely involved in the pathogenesis of type 2 diabetes as well as role this inflammatory condition cannot be ruled out in involvement in pathogenesis of type 1 diabetes. Since maximum world populations are at high risk of developing diabetes, we tested this hypothesis by estimating circulating acute phase proteins in freshly diagnosed type 2 (T-2) as well as type1(T-1) diabetic patients.

The acute phase proteins, Ī±1- antitrypsin, Ī±1- acid glycoprotein, ceruloplasmin and fibrinogen were estimated in the plasma in freshly diagnosed twenty-five T-2 cases and twelve T-1cases. Thirty normal controls to match the age and sex of the test groups were also studied. The levels of these proteins were correlated with their BMI and random plasma glucose values.



In comparison with the controls, the values of all the four proteins studied were significantly elevated in the T-2 patients (p<00001). In case of T-1 patient level of ceruloplasmin and fibrinogen are significantly elevated. Interestingly, no correlation was found with BMI or the degree of hyperglycemia in either of the types. A low-grade inflammatory process is definitely implicated in the pathogenesis of type 2 diabetes. Same can be ruled out in type-1 diabetic patients also. The comparative study of the states of all these inflammatory markers in case of T-2 and T-1 patients is of interest in this present study.



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Monday, February 4, 2019

Diabetes and Obesity Journals- Lupine Publishers



Just the other day, I wrote an Editorial for another journal on World Diabetes Day. Before that, it was the World Thrombosis Day. Think of just metabolic diseases, you have, - World Hypertension Day (May 17), World Obesity Day (Oct 11), World Heart Day (Sept 29), World Thrombosis Day (Oct 13), World Diabetes Day (Nov 14). The list keeps growing every year. Whenever I am asked to participate, in these World Observation Days or asked to write about these important annual days, I ask myself, what have we done to arrest, reduce or prevent these chronic metabolic diseases? What can be done about the raising epidemics of chronic diseases? These are hard questions to ask? Much harder, to answer.

All that we can do is, just like we do for New Year’s Day, take a pledge to do something that will make a difference. Metabolicdiseases, such as hypertension, excess weight, obesity, type-2 diabetes, and vascular diseases, have reached epidemic proportions worldwide. In the last three decades globally, obesity has increased two-fold and diabetes, four-fold. No country has stopped, reversed or prevented the trends, in the increase of these chronic metabolic diseases. We and others are of the opinion, that if the metabolic risks are recognized earlier, then just lifestyle modifications may be enough to prevent or postpone the development of diabetes and associated chronic clinical complications.


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Thursday, November 22, 2018

Resveratrol-based Nutraceuticals for the Management of Diabetes and Obesity: Real Therapeutic Potential or a mere Palliative?: (ADO)- Lupine Publishers



It is well known that obesity and diabetes (more specifically, the type 2 diabetes mellitus, T2DM) are currently a growing public health problem, which involves several millions subjects in the World. Years ago, indeed, the term “diabesity” was coined highlighting not only the strong pathogenic relationship between obesity and T2DM, but also the pandemic aspect that link these two diseases. The increasing global prevalence of diabesity represents a grave concern in terms of public health and, at the same time, medical costs, resulting in a serious social economic issue.


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Sunday, November 18, 2018

Associated Risk Factors in Pre-diabetes and Type 2 Diabetes in Saudi Community: (ADO)- Lupine Publishers



Background and Objective: The prevalence and incidence of type 2 diabetes mellitus (T2DM) are increasing worldwide. Pre diabetes is a high-risk state for the development of diabetes and its associated complications. This study aims to determine the associated risk factors among T2DM and pre diabetes patients among adult Saudi population.
Methods: For the present study, we analyzed participants who are older than 20 years old and had undergone a blood test to assess HbA1c. A total of 1095 were selected to be enrolled for the present study. All patients were from the population of the Primary health and Diabetic Centres at King Fahad Armed Forces Hospital. Participants were defined as having T2DM according to self-report, clinical reports, use of anti diabetic agents and HbA1c (≥6.5). Non T2DM participants were divided into normoglycemic or pre diabetic group as follows: HbA1c < 5.7, (normoglycemic) or HbA1c 5.7-6.4 (pre diabetes). Laboratory assessments included HbA1c, lipids, creatinine and urinary micro albumin.
Main results: Of the 1095 participants analyzed, 796 were women (72.7%). Age was 45.1±11.1 and BMI was 30.7±5.7. Hypertension had been diagnosed in 415 (38.2%) participants. Blood measurements revealed the following values: creatinine 68.2±22.0umol/L , Urine micro albumin (g/min) 55.4±200.3, total cholesterol levels 4.9±1.0mmol/L, high density lipoprotein 1.3±0.3mmol/L, triglyceride levels 1.5±0.7 and low density lipoprotein 3.0±0.9mmol/L. Of the overall 1095 analyzed participants, pre diabetes was present in 362(33.1%), 368(33.6%) were classified as T2DM and 365 (33.3%) as normoglycemic. When comparing pre diabetic with normoglycemic and T2DM population, pre diabetic subjects were more likely to have hypertension and higher triglyceride than normoglycemic but less than T2DM subjects. In addition, pre diabetic patients compared with T2DM ones had higher levels of low density lipoprotein and high density lipoprotein. Logistic regression analysis showed no significant association of any of the co variables with normoglycemic subjects in front of the pre diabetic reference group, whereas the odds of being in the diabetic group gets multiplied by 7.56 for each unitary increase in male gender (p< 0.0001, OR: 7.56, 95% CI 3.16-18.23). Also, individuals with hypertension had higher odds of being in the DM group than in the prediabetic (p<0 .0001, OR: 6.06, 95% CI 3.25- 11.28). Age of subjects had lower odds of being in the DM group than in the pre diabetic (p<0 .0001, OR: 0.85, 95% CI (0.82-0.89).

Conclusion: This study found the major clinical differences between pre diabetic and T2DM Patients were the higher hypertension and hypertriglyceridenia in the T2DM patients. Clearly, despite the small sample size, this study has posed important public health issues that require immediate attention from the health authority. Unless immediate steps are taken to contain the increasing prevalence of obesity, diabetes, pre diabetes, the health care costs for chronic diseases will pose an enormous financial burden to the country.

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Monday, November 12, 2018

Depression‐Level Effectiveness of the Curse Words in Young Adults in Pune University: (ADO) - LupinePublishers



Depression and substance abuse has on the increase all over the world. The poor and the rich are also involved in this dangerous habit that has impact not only on reproductive health but also has an impact on family, society, increase in health care expense and increased criminal activity. Health care providers have more concerned with treating the victims and less concerned on its prevention. Pregnant women bear a greater brunt and there has adverse pregnancy outcome. Low birth weight, preterm labour, increased in miscarriage and raised perinatal mortality has some of the adverse effects. Children of such parents have more likely to inherit this bad trait. Children living in abusive homes where drugs and alcohol abuse occur simultaneously has often deprived of more than just the basics of food and shelter. Depression has, any act on the part of the husband, partner or family which causes physical, mental, social or psychological trauma to the woman and prevent shier from developing her personality. Reason for the increase in depression violence has; urbanization, industrialization, growth of urban slums, co-education and co-working in offices and factories, modern movies, television, obscene and pornographic literature and decreasing religious restrictions.

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Sunday, November 11, 2018

Prevalence of Obesity and Association with Adherence to Mediterranean Diet in Medical, Nursing and Administrative Staff of a Greek Public Hospital: (ADO)- Lupine Publishers


Obesity is currently considered to be the most common metabolic disease. During the last decades, its incidence has dramatically risen both in developed and developing countries. Several studies of the health of healthcare professionals have found that a significant proportion is obese. Obesity among the workforce may impede the efficacy of healthcare professionals health promotion efforts. The Mediterranean diet is considered to be a sustainable and healthy lifestyle pattern that promotes good health and disease prevention throughout the lifespan.
The objectives of the present study were
a) To determine the prevalence of obesity and obesity related lifestyle parameters (work anxiety, physical activity).
b) To investigate the association between adherence to Mediterranean diet and Body Mass Index (BMI) among health professionals.

c) To compare these parameters between medical doctors, administrative staff and nurses working at one selected public hospital. The perceptions of health professionals regarding their own body weight were also assessed and compared to their actual weight.

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Friday, November 9, 2018

Diet, Obesity and Diabetes: ADO- Lupine Publishers



Obesity and diabetes have become a very important global problem. In developed countries the incidence of both seems to have stabilised probably due to greater awareness and better education. Weight reduction in obese subjects with diabetes can be achieved by bariatric surgery and often results in remission of diabetes, hypertension and dyslipidaemia but at a cost of mortality and morbidity. Dietary intervention until recently has been relatively unsuccessful. Recently however, structured, low calorie diet with nurse/dietician support in a general practice setting has shown promise. Successful drug therapy to aid weight reduction remains elusive.

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Thursday, November 8, 2018

Evaluation of the Prevalence of Gestational Diabetes Using Fasting Blood Glucose and Glycated Heamoglobin in Yenagoa Metropolis: ADO- Lupine Publishers



There is understanding that most pregnant women with gestational diabetes mellitus stands the risk of having adverse obstetric and perinatal outcome. The need for an early detection and effective management of this problem with a view to ensure better maternal and fetal protection was the driving thrust for this study. Through the application of spectrophotometric methods employing enzymatic and non-enzymatic systems, the concentration of fasting blood glucose (FBG) and glycated Haemoglobin (HbA1c) were determined in 2nd and 3rd trimester pregnant women and compared with non-pregnant women. Data were analysed using student’s t-test with the aid of Graph pad Prism (R) software version 6.10 at p<0.05 values considered statistically significant. Result reveals that 11% of pregnant women investigated had gestational diabetes mellitus in Yenagoa metropolis. Our findings elucidate the danger of gestational diabetes mellitus, its prevalence and the need to allow for effective proactive intervention program regarding screening and management and in addition highlight areas requiring further research.

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Wednesday, November 7, 2018

Nocuous Skin Manifestations of Spironolactone: Drug Induced Leukocytoclastic Vasculitis: ADO- Lupine Publishers



The author discusses a case of drug induced vasculitis caused by spironolactone which is very rare complication of the drug. The authors give account on the type of vasculitis caused by drug induced allergy and also the differential diagnoses if the presentation is unusual with only hematuria and kidney injury. The benefits of Spironolactone and the side effects are also illustrated.

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Monday, November 5, 2018

Integration of Novel Emerging Technologies for the Management of Type-2 Diabetes: ADO - Lupine Publishers



The incidence of twin epidemics, obesity and type-2 diabetes are increasing rapidly worldwide in the past two decades [1-7]. By azand large, clinicians manage diabetes by meticulous management of blood glucose levels to meet the guidelines established by professional societies and regulatory agencies (8, 9). The American College of Physicians (ACP) published the most recent guideline in April of this year (8).

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Lupine Publishers| Semaglutide versus liraglutide for treatment of obesity

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