Comparative Study of Degree of Low Grade Chronic Inflammatory Status in Freshly Diagnosed Type 1 with Type 2 Diabetic Patients by Shamim Shaikh Mohiuddin in Archives of Diabetes & Obesity in Lupine Publishers
Low grade inflammatory condition which is predominately
cytokine-mediated is observed to be closely involved in the
pathogenesis of type 2 diabetes as well as role this inflammatory
condition cannot be ruled out in involvement in pathogenesis of
type 1 diabetes. Since maximum world populations are at high risk of
developing diabetes, we tested this hypothesis by estimating
circulating acute phase proteins in freshly diagnosed type 2 (T-2) as well as type1(T-1) diabetic patients.
The acute phase proteins, α1- antitrypsin, α1- acid glycoprotein, ceruloplasmin and fibrinogen were estimated in the plasma in
freshly diagnosed twenty-five T-2 cases and twelve T-1cases. Thirty
normal controls to match the age and sex of the test groups were
also studied. The levels of these proteins were correlated with their
BMI and random plasma glucose values.
In comparison with the controls, the values of all the four proteins
studied were significantly elevated in the T-2 patients
(p<00001). In case of T-1 patient level of ceruloplasmin and fibrinogen are significantly elevated. Interestingly, no correlation was
found with BMI or the degree of hyperglycemia in either of the types. A
low-grade inflammatory process is definitely implicated in
the pathogenesis of type 2 diabetes. Same can be ruled out in type-1
diabetic patients also. The comparative study of the states of all
these inflammatory markers in case of T-2 and T-1 patients is of
interest in this present study.
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